Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq Based Transcriptomic Map Reveals New Insights Into Mouse Salivary Gland Development and Maturation

ABSTRACT: Analysis of gene expression changes during mouse salivary gland development using RNA-Seq

ORGANISM(S): Mus musculus

PROVIDER: GSE81097 | GEO | 2016/10/05

SECONDARY ACCESSION(S): PRJNA320508

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Epigenomic Based Identification of the Global Gene Regulatory Map of the Murine Salivary Gland

Project description:The characterization of the epigenetic landscape of mouse salivary gland epithelial cells via histone modification ChIP-Seq and whole tissue RNA-Seq Analysis

2021-06-01 | GSE145753 | GEO

The role of IRF6 in salivary gland development

Project description:Loss of Irf6 leads to disruption of branching morphogenesis and secretory acnii formation in salivary gland. To determine the differentially expressed genes in Irf6 mutant, embryonic salivary gland tissues were extracted at E14.5.

2017-07-29 | GSE102020 | GEO

Gene expression of murine 3 major salivary gland organoids

Project description:Salivary glands that produce and secret saliva, which is essential for lubrication, digestion, immunity, and oral homeostasis, consist of diverse cells. The long-term maintenance of diverse salivary gland cells in organoids remains problematic. Here, we established long-term murine salivary gland organoids from 3 major salivary glands, including parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG). Murine salivary gland organoids expressed gland-specific genes and proteins of acinar, myoepithelial, and duct cells. Organoids were maintained in growth media (named GEM) and further underwent differentiation in differentiation media (named DAM). Our study will provide an experimental platform for the exploration of mechanisms involvled in tissue regeneration, development, or several salivary gland diseases.

2022-05-05 | GSE184091 | GEO

Ionizing Radiation-induced Acute Damage in the Salivary Gland

Project description:Ionizing radiation (IR) – induced salivary gland damage is a common adverse effect in radiotherapy for patients with head and neck cancers. Currently, there is no effective treatment for the resulting salivary gland hypofunction and xerostomia (dry mouth). Here we profiled the acute gene expression change in the mouse submandibular salivary gland, and defined its damage response patterns at the transcriptome level.

2021-09-23 | GSE184673 | GEO

Gene expression analysis of human salivary gland and organoid at single cell resolution

Project description:Salivary glands that produce and secret saliva, which is essential for lubrication, digestion, immunity, and oral homeostasis, consist of diverse cells. Maintenance of diverse salivary gland cells in organoids remains problematic. Here, we established human salivary gland organoids, which is composed of multiple cellular subsets, from 3 major salivary glands, including parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG). Human salivary gland organoids expressed gland-specific genes and proteins of acinar, myoepithelial, and duct cells. Organoids were maintained in growth media (named GEM) and further underwent differentiation in differentiation media (named DAM). Our study will provide an experimental platform for the exploration of mechanisms involvled in tissue regeneration, development, or several salivary gland diseases.

2022-05-05 | GSE184526 | GEO

DNA methylation profiling of salivary gland tumors

Project description:Tumors of the major and minor salivary gland encompass a diverse spectrum of diagnostically challenging neoplasms. Recent studies have identified several gene fusions and somatic mutations that are specific or highly enriched in certain salivary gland tumor entities and can assist histopathological diagnosis. Still, there is an unmet need to identify additional diagnostic biomarkers for entities lacking specific alterations. In this study, we collected a comprehensive cohort of 363 cases encompassing 20 different salivary gland tumor entities and explored the potential of DNA methylation to classify these tumors. We were able to show that most entities show specific epigenetic signatures and present a machine learning algorithm that can be used to classify diagnostically challenging cases.

2024-08-31 | GSE243075 | GEO

Gene expression data from AKT induced salivary gland tumors

Project description:Rapamycin treatment of AKT induced salivary gland tumors

2013-01-14 | GSE23435 | GEO

Purification and ex vivo expansion of fully functional salivary gland stem cells

Project description:Analysis of genes that are enriched in long-term self-renewing salivary gland stem cells. And analysis of genes that are enriched in the organoids containing differentiated salivary gland cells.

2014-11-01 | GSE59559 | GEO

Differential expression of Aedes aegypti salivary gland transcriptome upon blood feeding

Project description:We have developed an oligoGEArray with 434 genes from Ae. aegypti salivary gland. OligoGEArray was customized with the salivary gland genes chosen from the transcriptome source published by Ribeiro et al (2007). Oligonucleotides (60bp) were designed and array were manufactured by SABiosciences. Using this OligoGEArray, we analyzed the differential expression of salivary trancritptome upon blood feeding.

2009-12-31 | GSE16392 | GEO

Gene fusion detection of salivary gland pleomorphic adenoma

Project description:Gene fusion detection of salivary gland pleomorphic adenoma

2021-05-31 | E-MTAB-9818 | biostudies-arrayexpress