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Transcriptional profiling of CD4+ T cells activated in murine malaria.

ABSTRACT: CD4+ T cells are critical for defense against the Plasmodium parasites that cause malaria. To better understand CD4+ T cell effector mechanisms during malaria, we performed microarray analysis of CD4+ T cells from naïve and infected mice. Comparison of activated (CD44 hi CD62L lo) CD4+ T cells from infected mice to bulk CD4+ T cells from naïve mice revealed a subset of genes that were upregulated by infection with Plasmodium chabaudi. These results help generate a more complete picture of CD4+ T cell function in malaria.

ORGANISM(S): Mus musculus

PROVIDER: GSE81196 | GEO | 2016/11/12

SECONDARY ACCESSION(S): PRJNA320886

REPOSITORIES: GEO

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