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MeDIP on the marine medaka sperm (Oryzias melastigma)

ABSTRACT: Hypoxia is amongst the most widespread and pressing problems in aquatic environments. For the first time, we demonstrate that fish (Oryzias melastigma) exposed to hypoxia show reproductive impairments in F2 generations despite these progenies (and their germ cells) having never been exposed to hypoxia. We further show that the observed transgenerational reproductive impairments are associated with a differential methylation pattern of specific genes in sperm of both F0 and F2.

ORGANISM(S): Oryzias melastigma

PROVIDER: GSE81312 | GEO | 2016/05/11

SECONDARY ACCESSION(S): PRJNA321309

REPOSITORIES: GEO

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Brain tissus of Oryzias melastigma under hypoxia, rep2

Project description:Hypoxia is amongst the most widespread and pressing problems in aquatic environments. Here we demonstrate that fish (Oryzias melastigma) exposed to hypoxia show reproductive impairments (retarded gonad development, decrease in sperm count and sperm motility) in F1 and F2 generations despite these progenies (and their germ cells) having never been exposed to hypoxia. We further show that the observed transgenerational reproductive impairments are associated with a differential methylation pattern of specific genes in sperm of both F0 and F2 coupled with relevant transcriptomic and proteomic alterations, which may impair spermatogenesis.

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