Glucocorticoid Receptor: MegaTrans Switching Mediates Repression of ERα-Regulated Transcriptional Program [Gro-Seq]
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ABSTRACT: The mechanisms underlying GR-dependent inhibition of ERα-regulated gene activation programs at the global genomic level have been poorly understood. We found the binding of GR in trans on ERα-activated enhancers results in gene and enhancer repression by disassembling the MegaTrans Complex.
ORGANISM(S): Homo sapiens
PROVIDER: GSE81511 | GEO | 2017/03/01
SECONDARY ACCESSION(S): PRJNA321837
REPOSITORIES: GEO
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