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Glucocorticoid Receptor: MegaTrans Switching Mediates Repression of ERα-Regulated Transcriptional Program [Gro-Seq]


ABSTRACT: The mechanisms underlying GR-dependent inhibition of ERα-regulated gene activation programs at the global genomic level have been poorly understood. We found the binding of GR in trans on ERα-activated enhancers results in gene and enhancer repression by disassembling the MegaTrans Complex.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81511 | GEO | 2017/03/01

SECONDARY ACCESSION(S): PRJNA321837

REPOSITORIES: GEO

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