Surface modified titanium dioxide nanoparticles induce fibrosis-like changes in lungs at high doses
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ABSTRACT:
ORGANISM(S): Mus musculus
PROVIDER: GSE81570 | GEO | 2016/12/07
SECONDARY ACCESSION(S): PRJNA322014
REPOSITORIES: GEO
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Project description:Previous studies have shown that TiO2NPs induce lung inflammation in mice and have suggested that the degree of inflammation varies with their size and other physical and chemical properties, e.g., shapes, surface modifications and surface charge. It is currently unknown if the observed inflammation in mouse lungs following exposure to TiO2NPs will cause any disease in the long term. This study examined mouse lung responses to six individual TiO2NPs of varying sizes (10, 20 and 300 nm), surface modifications and shapes. C57BL/6 mice were exposed to 18 µg, 54 µg, 162 µg or 486 µg of TiO2NPs/mouse via direct deposition of particles in lungs. Lung fluid and lung tissue were sampled on day 1, day 28 and day 90. Changes in inflammation and gene expression in lung were profiled. Histopathological changes in lungs indicative of diseases were examined by microscopic techniques. The results confirmed that all TiO2NPs induce lung inflammation immediately after exposure. At the highest dose tested, this particular TiO2NPs with surface modification induced signs of lung fibrosis (a disease of regulatory importance for NMs. Although lung response induced by TiO2NPs is influenced by many of their properties, the results of the study indicated that certain surface modification may play role in causing a disease.
2016-12-07 | GSE81564 | GEO
Project description:Previous studies have shown that TiO2NPs induce lung inflammation in mice and have suggested that the degree of inflammation varies with their size and other physical and chemical properties, e.g., shapes, surface modifications and surface charge. It is currently unknown if the observed inflammation in mouse lungs following exposure to TiO2NPs will cause any disease in the long term. This study examined mouse lung responses to six individual TiO2NPs of varying sizes (10, 20 and 300 nm), surface modifications and shapes. C57BL/6 mice were exposed to 18 µg, 54 µg, 162 µg or 486 µg of TiO2NPs/mouse via direct deposition of particles in lungs. Lung fluid and lung tissue were sampled on day 1, day 28 and day 90. Changes in inflammation and gene expression in lung were profiled. Histopathological changes in lungs indicative of diseases were examined by microscopic techniques. The results confirmed that all TiO2NPs induce lung inflammation immediately after exposure. At the highest dose tested, this particular TiO2NPs with surface modification induced signs of lung fibrosis (a disease of regulatory importance for NMs. Although lung response induced by TiO2NPs is influenced by many of their properties, the results of the study indicated that certain surface modification may play role in causing a disease.
2016-12-07 | GSE81566 | GEO
Project description:Previous studies have shown that TiO2NPs induce lung inflammation in mice and have suggested that the degree of inflammation varies with their size and other physical and chemical properties, e.g., shapes, surface modifications and surface charge. It is currently unknown if the observed inflammation in mouse lungs following exposure to TiO2NPs will cause any disease in the long term. This study examined mouse lung responses to six individual TiO2NPs of varying sizes (10, 20 and 300 nm), surface modifications and shapes. C57BL/6 mice were exposed to 18 µg, 54 µg, 162 µg or 486 µg of TiO2NPs/mouse via direct deposition of particles in lungs. Lung fluid and lung tissue were sampled on day 1, day 28 and day 90. Changes in inflammation and gene expression in lung were profiled. Histopathological changes in lungs indicative of diseases were examined by microscopic techniques. The results confirmed that all TiO2NPs induce lung inflammation immediately after exposure. At the highest dose tested, this particular TiO2NPs with surface modification induced signs of lung fibrosis (a disease of regulatory importance for NMs. Although lung response induced by TiO2NPs is influenced by many of their properties, the results of the study indicated that certain surface modification may play role in causing a disease.
2016-12-07 | GSE81565 | GEO
Project description:Previous studies have shown that TiO2NPs induce lung inflammation in mice and have suggested that the degree of inflammation varies with their size and other physical and chemical properties, e.g., shapes, surface modifications and surface charge. It is currently unknown if the observed inflammation in mouse lungs following exposure to TiO2NPs will cause any disease in the long term. This study examined mouse lung responses to six individual TiO2NPs of varying sizes (10, 20 and 300 nm), surface modifications and shapes. C57BL/6 mice were exposed to 18 µg, 54 µg, 162 µg or 486 µg of TiO2NPs/mouse via direct deposition of particles in lungs. Lung fluid and lung tissue were sampled on day 1, day 28 and day 90. Changes in inflammation and gene expression in lung were profiled. Histopathological changes in lungs indicative of diseases were examined by microscopic techniques. The results confirmed that all TiO2NPs induce lung inflammation immediately after exposure. At the highest dose tested, this particular TiO2NPs with surface modification induced signs of lung fibrosis (a disease of regulatory importance for NMs. Although lung response induced by TiO2NPs is influenced by many of their properties, the results of the study indicated that certain surface modification may play role in causing a disease.
2016-12-07 | GSE81569 | GEO
Project description:Previous studies have shown that TiO2NPs induce lung inflammation in mice and have suggested that the degree of inflammation varies with their size and other physical and chemical properties, e.g., shapes, surface modifications and surface charge. It is currently unknown if the observed inflammation in mouse lungs following exposure to TiO2NPs will cause any disease in the long term. This study examined mouse lung responses to six individual TiO2NPs of varying sizes (10, 20 and 300 nm), surface modifications and shapes. C57BL/6 mice were exposed to 18 µg, 54 µg, 162 µg or 486 µg of TiO2NPs/mouse via direct deposition of particles in lungs. Lung fluid and lung tissue were sampled on day 1, day 28 and day 90. Changes in inflammation and gene expression in lung were profiled. Histopathological changes in lungs indicative of diseases were examined by microscopic techniques. The results confirmed that all TiO2NPs induce lung inflammation immediately after exposure. At the highest dose tested, this particular TiO2NPs with surface modification induced signs of lung fibrosis (a disease of regulatory importance for NMs. Although lung response induced by TiO2NPs is influenced by many of their properties, the results of the study indicated that certain surface modification may play role in causing a disease.
2016-12-07 | GSE81568 | GEO
Project description:Previous studies have shown that TiO2NPs induce lung inflammation in mice and have suggested that the degree of inflammation varies with their size and other physical and chemical properties, e.g., shapes, surface modifications and surface charge. It is currently unknown if the observed inflammation in mouse lungs following exposure to TiO2NPs will cause any disease in the long term. This study examined mouse lung responses to six individual TiO2NPs of varying sizes (10, 20 and 300 nm), surface modifications and shapes. C57BL/6 mice were exposed to 18 µg, 54 µg, 162 µg or 486 µg of TiO2NPs/mouse via direct deposition of particles in lungs. Lung fluid and lung tissue were sampled on day 1, day 28 and day 90. Changes in inflammation and gene expression in lung were profiled. Histopathological changes in lungs indicative of diseases were examined by microscopic techniques. The results confirmed that all TiO2NPs induce lung inflammation immediately after exposure. At the highest dose tested, this particular TiO2NPs with surface modification induced signs of lung fibrosis (a disease of regulatory importance for NMs. Although lung response induced by TiO2NPs is influenced by many of their properties, the results of the study indicated that certain surface modification may play role in causing a disease.
2016-12-07 | GSE81567 | GEO
Project description:Surface modified titanium dioxide nanoparticles induce fibrosis-like changes in lungs at high doses
| PRJNA322014 | ENA
Project description:This project utilized oligonucleotide microarrays to examine gene expression patterns in adult male fathead minnows (Pimephales promelas) exposed to a common nanomaterial, titanium dioxide (TiO2, stearate-coated particles, MT-100TV®). We exposed adult male fathead minnows for 96 hr to three doses (0, 1, and 10 mg/L nominal) of TiO2 under static renewal conditions. TiO2 is stearate coated, 15 nm particle size.
2010-12-22 | GSE17902 | GEO
Project description:This project utilized oligonucleotide microarrays to examine gene expression patterns in adult male fathead minnows (Pimephales promelas) exposed to a common nanomaterial, titanium dioxide (TiO2, stearate-coated particles, MT-100TV®). We exposed adult male fathead minnows for 96 hr to three doses (0, 1, and 10 mg/L nominal) of TiO2 under static renewal conditions. TiO2 is stearate coated, 15 nm particle size. Three-condition experiment: high dose, controls (untreated, low dose). Three tissues: liver, gill, brain. Biological replicates: 4 control replicates, 4 low dose, 4 high dose for gill and liver. One array for brain control and low dose; and 2 arrays for brain high dose. Contributor: Johnson & Johnson Worldwide Envrionmental
2010-12-22 | E-GEOD-17902 | biostudies-arrayexpress
Project description:Acute phase reactants serum amyloid A-1, 3 and micro RNA-135b, -449a, and -1 are induced in lungs of mice exposed to subtoxic doses of nano-titanium dioxide particles by inhalation In the present study we investigate pulmonary mRNA and miRNA profiles of mice exposed to subtoxic dose of nano-titanium dioxide particles by inhalation. We show dramatic induction of acute phase reactants, chemoattractants, immune and host defence related genes. We also demonstrate for the first time changes in miRNA profiles in the lungs in response to nanoTiO2. Keywords: Toxicology, disease state analysis, biomarkers of health effects
2010-12-13 | GSE19487 | GEO