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Transcriptome response to endoplasmic reticulum stress in rat oligodendrocyte precursor cells

ABSTRACT: In the US, there are approximately 12,000 new cases of traumatic spinal cord injury (SCI) each year. Currently there are no neuroprotective treatments to improve outcome of SCI. Our previous research has revealed that endoplasmic reticulum stress response (ERSR) is an important contributor to oligodendrocyte death and subsequent white matter loss and locomotor impairment after contusive spinal cord injury in mice. ERSR affects activity of multiple transcription factors regulating either pro-survival- or apoptosis-promoting genes. Therefore, we characterized transcriptomic changes in ERSR-challenged oligodendrocytes as a first step to identify new targets for therapies that may attenuate their loss after SCI.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE81792 | GEO | 2022/05/15

REPOSITORIES: GEO

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