Methylation profiling

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Methylation Profiling of IGHV Unmutated vs mutated CLL


ABSTRACT: In the present study, the methylation profiling (MeDIP) was carried out in 14 treatment-naive, early stage (Rai stage 0-2) CLL patients and pooled 19+ normal controls. To find an association of methylation with IGHV mutation status, CLL patients were further segregated into IGHV unmutated (n=9) and IGHV mutated (n=5) subgroups. The methylation signature obtained for CLL versus nornal controls and; unmutated versus mutated CLL was integrated with gene expression profile of these patients and the results were correlated with clinical outcome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE81936 | GEO | 2017/05/29

SECONDARY ACCESSION(S): PRJNA323466

REPOSITORIES: GEO

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