Transcriptomics

Dataset Information

0

Characterization of expression quantitative trait loci in extensively phenotyped pedigrees from Colombia and Costa Rica


ABSTRACT: The observation that variants regulating gene expression (expression quantitative trait loci, eQTL) are at a high frequency among SNPs associated with complex traits has made the genome-wide characterization of gene expression an important tool in genetic mapping studies of such traits. As part of a study to identify genetic loci contributing to bipolar disorder and a wide range of BP-related quantitative traits in members of 26 pedigrees from Costa Rica and Colombia, we measured gene expression in lymphoblastoid cell lines derived from 786 pedigree members. The study design enabled us to comprehensively reconstruct the genetic regulatory network in these families, provide estimates of heritability, identify eQTL, evaluate missing heritability for the eQTL, and quantify the number of different alleles contributing to any given locus.

ORGANISM(S): Homo sapiens

PROVIDER: GSE82042 | GEO | 2016/07/01

SECONDARY ACCESSION(S): PRJNA323740

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-07-01 | E-GEOD-82042 | biostudies-arrayexpress
2014-05-01 | GSE54089 | GEO
2010-12-16 | E-GEOD-26091 | biostudies-arrayexpress
2014-05-01 | E-GEOD-54089 | biostudies-arrayexpress
2010-12-16 | GSE26091 | GEO
2022-05-21 | GSE203482 | GEO
2015-06-29 | E-GEOD-65907 | biostudies-arrayexpress
2014-10-31 | E-GEOD-50027 | biostudies-arrayexpress
2019-02-11 | GSE115828 | GEO
2011-06-24 | E-GEOD-22564 | biostudies-arrayexpress