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FAS signalling in retroviral neuroinflammation

ABSTRACT: We comprehensively explored Fas expression (protein and mRNA) and function in lymphocyte activation, apoptosis, proliferation and transcriptome, using flow cytometry, [3H]-thymidine incorporation and microarray analysis in PBMC from HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE82160 | GEO | 2017/02/01

SECONDARY ACCESSION(S): PRJNA324236

REPOSITORIES: GEO

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Functional difference in the HTLV-1 subgroup specific viral transcriptional regulators Tax and HBZ

Project description:Among HTLV-1-infected individuals, the lifetime risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is associated with the HTLV-1 gene subgroup (i.e., subgroup-A or -B) in Japan. The purpose of this study is to understand the molecular mechanism responsible for this association.

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