Genomics

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Cytosine modifications modulate the chromatin architecture of transcriptional enhancers


ABSTRACT: The dynamics of cytosine modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been correlated with activation of transcriptional enhancers. However, their functional relationship with the regulation of enhancer activity by pioneer transcription factors remains elusive. To gain insights into their function, we interrogated chromatin characteristics of enhancers bound by the pioneer factors FOXA1, MEIS1 and PBX1at different ime points during differentiation of mouse embryonal carcinoma cells into neural progenitors.

ORGANISM(S): Mus musculus

PROVIDER: GSE82314 | GEO | 2017/03/03

SECONDARY ACCESSION(S): PRJNA324606

REPOSITORIES: GEO

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