Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins
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ABSTRACT: Purpose: This study uses a high-throughput glycan microarray to profile anti-glycan immune responses to whole-cell vaccines: GVAX Pancreas, K562-GM and H1299. The aim was to indentify anti-glycan antibody responses relevent to patient clinical outcomes Results: Immune responses to non-human antigens bovine fetuin and alpha-Gal antigens were identified induced by GVAX Pancreas. The magnitude of these responses inversely correlate with patient survival. The non-human antigens were likely incorporated from cell media used for vaccine production. Their presence distracted immune system, resulting in decreased immune response to vaccine antigens. Conclusion: This study highlighted the importance of anti-glycan immune response in vaccine development. Whole-cell vaccinesderived from human cell lines could incorporate non-human antigens from cell media. These xeno-antigens may have negative impact on the vaccine efficacy.
ORGANISM(S): Dermestes lardarius Bos taurus Mus musculus Homo sapiens Human immunodeficiency virus 1 Oryctolagus cuniculus Trypanosoma cruzi Ovis aries Frangula alnus Gossypium hirsutum Pachymenia carnosa Ceratonia siliqua Quercus alba Pandalus borealis Megathura crenulata Senegalia senegal Gallus gallus Bothrops moojeni Oncorhynchus nerka
PROVIDER: GSE83087 | GEO | 2016/12/13
SECONDARY ACCESSION(S): PRJNA324714
REPOSITORIES: GEO
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