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RNA-Sequencing of HDLEC treated with siRNA targeting PROX1 and TIE2

ABSTRACT: We analyzed genome-wide transcriptional changes induced by siPROX1 and siTIE2, using RNA-seq analysis of HDLECs in order to highlight the importance of Ang-Tie2 system in SC and lymphatic development. Here, we report that coordination between both Ang1- and Ang2-signaling via Tie2 and Prox1 activity are essential for the appropriate formation of SC during development and maintenance of SC integrity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE83299 | GEO | 2017/09/01

REPOSITORIES: GEO

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