Evaluation of autoantibody signatures in meningioma patients using human proteome array
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ABSTRACT: Our objective was to identify the potential autoantibody markers in meningiomas using high-density human proteome arrays (~17,000 full-length recombinant human proteins). This study revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of signalling pathways which play a major role in the manifestation of the disease. This study revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of signalling pathways which play a major role in the manifestation of the disease. Autoantibody targets like IGHG4, CRYM, EFCAB2, STAT6, HDAC7A and CCNB1 were dysregulated across both grades.
ORGANISM(S): Homo sapiens
PROVIDER: GSE83507 | GEO | 2016/06/21
SECONDARY ACCESSION(S): PRJNA326211
REPOSITORIES: GEO
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