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SNP arrays of BT474 Latpatinib and/or Trastuzumab resistant cell lines for copy number analysis.

ABSTRACT: Targeting HER2 with lapatinib (L), trastuzumab (T), or the LT combination, is effective in HER2+ breast cancer (BC), but de novo and acquired resistance commonly occur. The purpose of this experiment was to investigate the somatic alterations found in Lapatinib and/or Trastuzumab resistant cells lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE83608 | GEO | 2019/06/21

REPOSITORIES: GEO

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A Phase II Randomized Trial of Neoadjuvant Trastuzumab or Lapatinib or the Combination of Trastuzumab and Lapatinib, Followed by Docetaxel and Carboplatin with Trastuzumab and/or Lapatinib in Patients with HER2+ Breast Cancer [Baseline]

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