Transcriptomics

Dataset Information

0

MiR-17-92 cluster regulates adult hippocampal neurogenesis, anxiety and depression


ABSTRACT: Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs), contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here we show altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact in neurogenesis and anxiety- and depression-related behaviors in mice. miR-17-92 deletion in adult neural progenitors causes a decrease, while its overexpression an increase of neurogenesis in the dentate gyrus, through regulating genes in the glucocorticoid pathway, especially serum- and glucocorticoid-inducible protein kinase-1 (Sgk1). miR-17-92 knockout mice show anxiety- and depression-like behaviors, whereas miR-17-92 overexpressing mice exhibit anxiolytic and antidepression-like behaviors. Furthermore, we show that miR-17-92 expression in the adult mouse hippocampus responds to chronic stress, and miR-17-92 rescues proliferation defects, induced by corticosterone, in hippocampal neural progenitors. Our study uncovers a crucial role for miR-17-92 in adult neural progenitors to regulate neurogenesis and anxiety- and depression-like behaviors.

ORGANISM(S): Mus musculus

PROVIDER: GSE83636 | GEO | 2016/12/09

SECONDARY ACCESSION(S): PRJNA326539

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA326539 | ENA
2019-06-17 | PXD012610 | Pride
2021-09-09 | PXD018052 | Pride
2011-05-04 | E-GEOD-29014 | biostudies-arrayexpress
2011-08-29 | E-GEOD-28999 | biostudies-arrayexpress
2019-11-13 | GSE124605 | GEO
2019-02-26 | GSE126888 | GEO
2019-11-10 | GSE123671 | GEO
2019-03-01 | GSE98089 | GEO
2014-03-07 | E-GEOD-52514 | biostudies-arrayexpress