Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Neutralizing Antibody Mediated Protection Against Mucosal Simian-Human Immunodeficiency Virus Challenge Includes Systemic Clearance of Distal Virus

ABSTRACT: The purpose of this study was to investigate the anatomic sites and mechanisms of antibody-mediated protection. In particular, to determine whether bNAbs completely block virus at the local portal of entry following mucosal virus challenge.

ORGANISM(S): Homo sapiens Macaca mulatta

PROVIDER: GSE83702 | GEO | 2016/09/01

SECONDARY ACCESSION(S): PRJNA326765

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Simian immunodeficiency virus

Project description:Simian immunodeficiency virus Variation

| PRJNA176620 | ENA

Simian immunodeficiency virus

Project description:Simian immunodeficiency virus overview

| PRJNA69627 | ENA

Simian immunodeficiency virus

Project description:Simian immunodeficiency virus Genome sequencing and assembly

| PRJNA317777 | ENA

Simian immunodeficiency virus strain:SIVmac251

Project description:Simian immunodeficiency virus strain:SIVmac251 Raw sequence reads

| PRJNA551921 | ENA

Simian immunodeficiency virus strain:SIVsmE660

Project description:Simian immunodeficiency virus strain:SIVsmE660 Genome sequencing and assembly

| PRJNA353516 | ENA

Simian immunodeficiency virus strain:SIVdeltaB670

Project description:Simian immunodeficiency virus strain:SIVdeltaB670 Genome sequencing and assembly

| PRJNA353138 | ENA

Simian immunodeficiency virus strain:SIVdeltaB670

Project description:Simian immunodeficiency virus strain:SIVdeltaB670 Genome sequencing and assembly

| PRJNA353237 | ENA

Simian immunodeficiency virus strain:SIVmac239deltanef

Project description:Simian immunodeficiency virus strain:SIVmac239deltanef Genome sequencing and assembly

| PRJNA479845 | ENA

Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection

Project description:Molecular basis for CNS dysfunction in simian immunodeficiency virus-infected rhesus monkeys. We used microarrays to identify differentially expressed genes in chronic simian immunodeficiency virus-infected rhesus monkeys.

2012-01-29 | GSE35397 | GEO

Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased binding affinity to Fcg receptors during acute SHIV infection shapes innate and adaptive cellular immunity [set2]

Project description:Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions in vitro have only been tested in NHPs during chronic simian-HIV (SHIV) infection. Here, we investigated the effects of administering in acute SHIVAD8-EO infection either wild-type (WT) bNAbs or bNAbs carrying the S239D/I332E/A330L (DEL) mutation, which increases binding to FcgRs. Emergence of plasma and lymph node (LN) virus was delayed in bNAb-treated monkeys and occurred earlier in monkeys given DEL bNAbs than in those given WT bNAbs, consistent with faster clearance of DEL bNAbs from plasma. DEL bNAb-treated monkeys had higher levels of circulating virus-specific IFNg single-producing and IFNg/MIP-1b double-producing CD8+ CD69+ T cells than the other groups. In LNs, WT bNAbs were evenly distributed between follicular and extrafollicular areas, but DEL bNAbs predominated in the latter. At week 8 post-challenge, LN monocytes and NK cells from DEL bNAb-treated monkeys upregulated proinflammatory signaling pathways and LN T cells downregulated TNF signaling via NF-kB. Overall, bNAbs with increased binding affinity to FcgRs shaped innate and adaptive cellular immunity, which may be important to consider in future strategies of passive bNAb therapy.

2024-07-23 | GSE254836 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data