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Gene regulation in ki-ras transfected murine fibroblasts

ABSTRACT: Ki-ras gene mutations are involved in the carcinogenesis of acute myeloid leukemia, melanoma and different carcinomas. In order to define potential mutation-specific therapeutic targets, expression profiling analyses were performed using stable transfected NIH3T3 cells carrying different ki-ras gene mutations. Maybe, this analysis allows the discorvery of ras-associated cellular mechanisms, which might lead to the identification of physiological targets for pharmacological interventions of the treatment of Ki-ras-associated human tumors. Keywords: cDNA microarray, murine fibroblast, ki-ras mutations, carcinogenesis

ORGANISM(S): Mus musculus

PROVIDER: GSE8372 | GEO | 2008/08/01

SECONDARY ACCESSION(S): PRJNA101403

REPOSITORIES: GEO

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Gene regulation in ki-ras transfected murine fibroblasts

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