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Crosstalk between androgen and proinflammatory signaling activates a distinct transcription program in prostate cancer cells

ABSTRACT: Crosstalk of androgen signaling induced with dihydrotestosterone (DHT) and proinflammatory signaling induced with tumor necrosis-factor alpha (TNFa) was analyzed in prostate cancer cells (LNCaP) by following chromatin binding of androgen receptor (AR), p65 (activating subunit of nuclear-factor kappa-B [NFkB]), FOXA1 and PIAS1+2 chromatin binding using ChIP-seq and transcriptional changes using GRO-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE83860 | GEO | 2016/10/05

SECONDARY ACCESSION(S): PRJNA327218

REPOSITORIES: GEO

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