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Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection [RNA-seq]

ABSTRACT: Abstract: Immune subversion represents a hallmark of persistent infection, but microbial suppression of B cell responses remains mechanistically ill-defined. Adoptive transfer experiments in a chronic viral infection model evidenced the rapid and profound decimation of B cells that responded to virus or to concomitantly administered protein. Decimation affected naïve and memory B cells and resulted from biased differentiation into short-lived antibody-secreting cells. It was driven by type I interferon (IFN-I) signaling to several cell types including dendritic cells, T cells and myeloid cells. Durable B cell responses were restored upon IFN-I receptor blockade or, partially, when depleting myeloid cells or key IFN-I-induced cytokines. B cell decimation represents a molecular mechanism of humoral immune subversion and reflects an unsustainable “all-in” response of B cells in IFN-I-driven inflammation.

ORGANISM(S): Mus musculus

PROVIDER: GSE84037 | GEO | 2016/09/19

SECONDARY ACCESSION(S): PRJNA327853

REPOSITORIES: GEO

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Type-I-Interferons induce the decimation of antiviral B cells at the onset of chronic infection [nanostring]

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