Transcriptomics

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MiR-34a and miR-34b/c suppress intestinal tumorigenesis in ApcMin/+ Mice


ABSTRACT: miR-34a and miR-34b/c genes are frequently epigenetically silenced in primary CRCs. However, the in vivo relevance of miR-34a/b/c for suppression of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletion of the miR-34a and miR-34b/c genes were generated and analyzed. The mRNA expression profiles of intestinal adenomas with and without functional miR-34a/b/c genes were compared.

ORGANISM(S): Mus musculus

PROVIDER: GSE84138 | GEO | 2017/05/28

SECONDARY ACCESSION(S): PRJNA328138

REPOSITORIES: GEO

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