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RNAseq analysis of quadriceps muscles from adult mice with constitutively active skeletal and cardiac muscle mTORC1 (through conditional knockout of Tsc1 under the Mck Cre) and their wild type litter mates

ABSTRACT: The purpose of this study was to determine how constitutively active mTORC1 signalling alters the transcriptome in skeletal muscle and determine how altered mTORC1 signaling influences the metabolic phenotype. We hypothesized that constitutively active skeletal muscle mTORC1 would lead to increased thermogenic capacity of the muscle and that this promotion of energy expenditure would be protective against diet-indued obesity

ORGANISM(S): Mus musculus

PROVIDER: GSE84312 | GEO | 2019/07/31

REPOSITORIES: GEO

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