The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation
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ABSTRACT: Here we have characterized the role of KDM5 family during adipocyte differentiation of 3T3-L1 preadipocytes. Notably, our study represents the first to simultaneously knock down all the KDM5 family members thereby avoiding interference from redundancy between KDM5 subtypes. Using a combination of knockdown and genome-wide ChIP-seq and RNA-seq analyses we uncover the underlying mechanisms of the inhibition of adipogenesis as well as basic aspects of KDM5 function.
ORGANISM(S): Mus musculus
PROVIDER: GSE84410 | GEO | 2016/12/01
SECONDARY ACCESSION(S): PRJNA329107
REPOSITORIES: GEO
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