Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response (UPR) pathway
Ontology highlight
ABSTRACT: We examined the transcriptional changes modulated by KDM1A inhibitor NCD-38 by performing global transcriptome analysis. Glioma Stem Cells (GSC10) were treated with either vehicle or NCD-38 for 24 h and the isolated RNA was utilized for RNA-seq analysis. Our results demonstrated that NCD-38 modulated several genes that are involved in unfolded protein response, endoplasmic reticulum stress pathway and NRF-2 mediated oxidative stress response.
ORGANISM(S): Homo sapiens
PROVIDER: GSE84603 | GEO | 2017/09/06
SECONDARY ACCESSION(S): PRJNA330614
REPOSITORIES: GEO
ACCESS DATA