Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic and stable enhancer-promoter contacts regulate terminal differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84662 | GEO | 2017/06/25

SECONDARY ACCESSION(S): PRJNA330783

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [HiC_CHiC]

Project description:Genome-wide chromosome conformation capture (Hi-C) and promoter-capture Hi-C (CHi-C) were performed during epidermal differentiation. These data indicate that dynamic and constitutive enhancer-promoter contacts combine to control gene induction during differentiation and that chromosome conformation enables discovery of new TFs with distinct roles in this process.

2017-06-28 | GSE84660 | GEO

Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [RNA-Seq]

2017-06-28 | GSE84661 | GEO

Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [ChIP-Seq]

2017-06-28 | GSE84657 | GEO

Dynamic and stable enhancer-promoter contacts regulate terminal differentiation [UMI-4C]

2017-06-28 | GSE95098 | GEO

Dynamic and stable enhancer-promoter contacts regulate terminal differentiation

Project description:Dynamic and stable enhancer-promoter contacts regulate terminal differentiation

| PRJNA330783 | ENA

Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.

Project description:Chromosome conformation is an important feature of metazoan gene regulation; however, enhancer-promoter contact remodeling during cellular differentiation remains poorly understood. To address this, genome-wide promoter capture Hi-C (CHi-C) was performed during epidermal differentiation. Two classes of enhancer-promoter contacts associated with differentiation-induced genes were identified. The first class ('gained') increased in contact strength during differentiation in concert with enhancer acquisition of the H3K27ac activation mark. The second class ('stable') were pre-established in undifferentiated cells, with enhancers constitutively marked by H3K27ac. The stable class was associated with the canonical conformation regulator cohesin, whereas the gained class was not, implying distinct mechanisms of contact formation and regulation. Analysis of stable enhancers identified a new, essential role for a constitutively expressed, lineage-restricted ETS-family transcription factor, EHF, in epidermal differentiation. Furthermore, neither class of contacts was observed in pluripotent cells, suggesting that lineage-specific chromatin structure is established in tissue progenitor cells and is further remodeled in terminal differentiation.

| S-EPMC5715812 | biostudies-literature

RNA polymerase II and PARP1 shape enhancer-promoter contacts

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-06-18 | GSE206133 | GEO

Identification of enhancer-promoter contacts in squamous cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-17 | GSE166234 | GEO

Mll3/Mll4 catalytic activity is necessary for de novo enhancer-promoter contacts during embryonic stem cell differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-28 | GSE160892 | GEO

C-terminal Mutations in RUNX1 Induce Differentiation Block and Alter Transcription through Changes in Enhancer-Promoter Interactions

Project description:This SuperSeries is composed of the SubSeries listed below.