Longitudinal transcriptomic and metabolomic data demonstrate altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic rats

ABSTRACT: Fat metabolism is also peturbed after the diagnosis of type 1 diabetes. Patients have less fat in the liver (4) and increased fasting lipid oxidation (5) compared to controls. Similarly, in a BioBreeding rat model of type 1 diabetes, the diabetes-prone animals develop a reduced respiratory quotient compared to non-diabetic rats before the onset of hyperglycemia, consistent with an increased use of fatty acids relative to carbohydrates as an energy substrate (6). We hypothesized that a lack of insulin reaching the liver contributes to the metabolic shift towards lipid oxidation observed in humans with type 1 diabetes and rodent models of the disease. To test our hypothesis, we measured changes in the hepatic gene expression and serum metabolome of a BioBreeding rat model of type 1 diabetes before and after the onset of hyperglycemia.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE84886 | GEO | 2017/06/12

SECONDARY ACCESSION(S): PRJNA335551

REPOSITORIES: GEO