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Expression data from liver, muscle and fat tissue of children with end stage liver disease

ABSTRACT: Cachexia, described as a syndrome of weight loss, muscle wasting, fat loss and insulin resistance has been described in patients with chronic liver disease. Whereas extensive work is being done to delineate these molecular pathways in adult patients with chronic liver or other disease, very little is known about these pathways in children with chronic liver disease. We used microarrays to detail the global programme of gene expression underlying the metabolic processes of cachexia in children with end stage liver disease udergoing liver transplantion. We included tissue from patients with Crigler-najjar syndrome as controls. We were able to identify distinct classes of differentially regulated genes related to these processes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE84954 | GEO | 2017/07/31

SECONDARY ACCESSION(S): PRJNA335743

REPOSITORIES: GEO

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