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Impact of Cugbp1 knockout on skeletal muscle and brain trancsriptome in neonatal mice

ABSTRACT: To elucidate the role of Cugbp1 knockout on the structure and function of skeletal muscle and brain, we have performed a microarray of mRNA obtained from skeletal muscle and brain samples obtained from neonatal WT and Cugbp1 KO mice. Between-genotype differences were assessed using a Student's T-test, with a p-value cutoff of 0.05 and fold change cutoff of 1.5. 929 genes were identified as differentially regulated; ontological enrichments within this geneset indicated Cugbp1 may regulate differentiation, extracellulat matrix and other muscle functions during myogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE85396 | GEO | 2018/08/08

REPOSITORIES: GEO

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Hepatic transcriptome in CUGBP1 S302A knock-in mice highlights CUGBP1 degradation by Gankyrin through diethylnitrosamine (DEN) activation, leading to fatty liver and liver cancer

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