Transcriptomics

Dataset Information

0

Perinatal Exposure to 2,2’,4’4’ –Tetrabromodiphenyl Ether Impairs Male Reproductive Health in Adult Rats


ABSTRACT: Toxicity of PBDE for male reproductive system was shown in several human and animal studies, however long lasting effects of perinatal exposures on male reproduction are yet poorly understood. In this study pregnant Wistar rats were exposed to 0.2 mg/kg 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) from gestation day 8 till postnatal day 21 and testis transcriptome was analyzed on postnatal day 120 in offspring. Exposed animals had significant change in testes transcriptome including suppression of genes essential for spermatogenesis and activation of immune response genes. In particular exposed animals had on average 4 fold decreased expression of protamine and transition protein genes in testes suggesting that histone-protamine exchange may be dysregulated in the course of spermatogenesis resulting in exposure legacy transfer to the next generation via aberrant sperm epigenome.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE85420 | GEO | 2019/08/10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-02-22 | GSE85221 | GEO
2010-01-13 | GSE19867 | GEO
2019-07-19 | GSE115143 | GEO
2019-07-17 | GSE134362 | GEO
2010-01-13 | GSE19868 | GEO
2020-07-22 | GSE154912 | GEO
2011-10-04 | E-GEOD-32156 | biostudies-arrayexpress
2011-10-05 | GSE32156 | GEO
| PRJNA445270 | ENA
2011-12-30 | E-GEOD-22674 | biostudies-arrayexpress