GPR41 modulates insulin secretion and gene expression in pancreatic beta-cells and modifies metabolic homeostasis in fed and fasting
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ABSTRACT: Insulin secretion by pancreatic b-cells is primarily regulated by glucose; however, hormones and additional nutrients, such as long-chain fatty acids, also play an important role in adjusting insulin output to physiologic needs. We examined the role of the short chain fatty acid receptor, GPR41, in funcion of pancreatic beta cells. GPR41 was specifically over-expressed in beta cells by using rat insulin promoter II (41 Tg).
ORGANISM(S): Mus musculus
PROVIDER: GSE85706 | GEO | 2016/08/17
SECONDARY ACCESSION(S): PRJNA339138
REPOSITORIES: GEO
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