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The impact of YTHDF2 knockout on the distribution of 5-methylcytosine in RNA

ABSTRACT: 5-methylcytosine is an important epigenetic modification found in both DNA and RNA. Transcriptome-wide mapping of 5-methylcytosine revealed that, after CRISPR-Cas9-mediated knockout of YTHDF2 gene, 545 sites displayed significant changes in 5-methylcytosine levels, with the majority of 5-methylcytosine sites in ribosomal RNA exhibiting substantially increased levels of methylation. Our data demonstrateda broader role of YTHDF2 in the post-transcriptional regulation of RNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE85887 | GEO | 2020/07/15

REPOSITORIES: GEO

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Microarray profiling of YTHDF2 deficient mouse oocytes

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