Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Inhibition of endothelial Notch signaling attenuates inflammation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE85987 | GEO | 2018/08/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Inhibition of endothelial Notch signaling attenuates inflammation

Project description:Inhibition of endothelial Notch signaling attenuates inflammation

| PRJNA339936 | ENA

Notch signaling in HSC

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2011-05-12 | E-GEOD-27833 | biostudies-arrayexpress

Inhibition of endothelial Notch signaling attenuates inflammation [ChIP-Seq]

Project description:Vascular endothelial cells upregulate the Notch ligand Jagged1 in response to inflammatory activation. Here we show that abrogation of endothelial Notch1 signaling impairs induction of key inflammatory target genes. Accordingly, inducible endothelial-targeted knockout of the canonical Notch transcription factor RBPJ reduces inflammation in a murine model of contact hypersensitivity, while overexpression of constitutive active Notch1 has the opposite effect. We show that the proinflammatory role of Notch1 can be attributed to direct genomic priming of the inflammatory landscape involving crosstalk with NF-κB/RelA and selective activation of enhancers associated with Notch-dependent inflammatory genes. This is the first evidence that canonical Notch signaling supports endothelial activation in response to inflammatory cytokines on the chromatin level.

2018-08-29 | GSE87552 | GEO

Endothelial TGFb signaling drives vascular inflammation and atherosclerosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-26 | GSE134558 | GEO

Heat shock protein 90 inhibition attenuates inflammation elicited by 12-O-tetradecanoylphorbol-13-acetate

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-31 | GSE222000 | GEO

A Primate lncRNA Mediates Notch Signaling During Neuronal Development by Sequestering miRNA

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-23 | E-GEOD-74210 | biostudies-arrayexpress

GATA3 restrains Notch signaling activity and represses NK cell development to induce human T cell commitment following Notch-induced T-lineage specification

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-06 | E-GEOD-71753 | biostudies-arrayexpress

Targeting Myc signaling pathway by inhibition of histone demethylase JMJD2B

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-01 | E-GEOD-45970 | biostudies-arrayexpress

Notch signaling in HSC

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-05-12 | GSE27833 | GEO

Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-12-04 | E-GEOD-63845 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data