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MiR-1199-5p and Zeb1: a novel double-negative feedback coordinating EMT and tumour cell invasion (mRNA-seq)

ABSTRACT: We investigated the effect of miR-1199-5p, miR-200b-3p and miR-429-3p on gene expression profiles during TGFbeta-induced EMT in normal murine mammary gland cells by using the mRNA-sequencing. Our analysis demonstrates that miR-1199-5p and both miR-200 family members share only 6 target genes, indicating that besides regulating Zeb1 expression they exert distinct functions during EMT.

ORGANISM(S): Mus musculus

PROVIDER: GSE86024 | GEO | 2017/11/09

SECONDARY ACCESSION(S): PRJNA340017

REPOSITORIES: GEO

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miR-1199-5p and Zeb1: a novel double-negative feedback coordinating EMT and tumour cell invasion

Project description:miR-1199-5p and Zeb1: a novel double-negative feedback coordinating EMT and tumour cell invasion

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miR-1199-5p and Zeb1: a novel double-negative feedback coordinating EMT and tumour cell invasion (miRNA-seq)

Project description:We performed miRNA-sequencing in a detailed time course of a TGFbeta-induced EMT in normal mammary gland cells and discovered 32 strongly, differentially expressed miRNAs.

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