Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea

ABSTRACT: We used RNA sequencing to compare the transcripts of the cochleae from control mice and from mice with β-catenin activation, Notch1 deletion, and β-catenin activation combined with Notch1 deletion in Sox2+ SCs. We identified the genes involved in the proliferation and transdifferentiation process that are either controlled by individual signaling pathways or by the combination of Wnt and Notch signaling. 

ORGANISM(S): Mus musculus

PROVIDER: GSE86204 | GEO | 2016/08/30

SECONDARY ACCESSION(S): PRJNA340885

REPOSITORIES: GEO