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Gene expression profiles (GEP) from melanocyte cell line (HeMa), and from two melanoma cell lines (M6 and A375)

ABSTRACT: In most solid tumors, the Warburg effect, also known as aerobic glycolysis, represents a major biochemical alteration associated with malignant transformation. Although the exact molecular mechanisms underlying this metabolic change remain to be clarified, the biochemical alteration in cancer cell energy metabolism opens novel avenues for the development of therapeutic strategies to preferentially kill cancer cells by targeting the glycolytic pathway. We used microarrays to focus on differences among A375, M6 melanoma cells and normal melanocytes (HeMa cells) in terms of glucose metabolism- and invasion-related properties. The transcript analysis showed that melanoma cells exhibit typical transcriptional features of a glycolytic phenotype, matched with high invasive markers (including increased expression of several matrix metallo-proteinases)

ORGANISM(S): Homo sapiens

PROVIDER: GSE86373 | GEO | 2016/09/02

SECONDARY ACCESSION(S): PRJNA341525

REPOSITORIES: GEO

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