Transcriptomics

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Gene expression profiling in three primary human cell lines treated with atorvastatin or an inhibitor of Rho kinase


ABSTRACT: Inhibitors of Rho kinase (ROCK) are a new class of drugs with potential benefit in oncology, neurology, and fibrotic and cardiovascular diseases. ROCK inhibitors modulate many cellular functions, some of which are similar to the pleiotropic (non-lipid lowering) effects of statins, suggesting additive or synergistic properties. Studies to date have used compounds which inhibit both isoforms of ROCK, ROCK1 and ROCK2. In this study, the effect of the newly developed ROCK2 inhibitor SLx-2119 on genome-wide gene expression was compared with atorvastatin in primary human cells. Keywords: Cell type comparison, agent comparison

ORGANISM(S): Homo sapiens

PROVIDER: GSE8686 | GEO | 2007/08/23

SECONDARY ACCESSION(S): PRJNA101901

REPOSITORIES: GEO

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