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Dermal fibroblasts play a central role in skin model protection against C. albicans invasion

ABSTRACT: This study shows that, in the presence of CD4+ T cells, dermal fibroblasts shift towards an antimicrobial phenotype leading to reduced dermal invasion by C. albicans. This is dependent on TLR2 activation and pro-IL-1β cleavage and results in expression of genes involved in defense against various classes of pathogens.

OTHER RELATED OMICS DATASETS IN: PRJNA343010

ORGANISM(S): Homo sapiens Candida albicans SC5314

PROVIDER: GSE86926 | GEO | 2017/07/01

SECONDARY ACCESSION(S): PRJNA343010

REPOSITORIES: GEO

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Dermal fibroblasts play a central role in skin model protection against C. albicans invasion

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