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C9/ALS Human Embryonic Stem Cells and C9/ALS Induced Pluripotent Stem Cells

ABSTRACT: We established two HESC lines with a C9 mutation (SZ-ALS1, SZ-ALS3) from embryos, which were obtained through preimplantation genetic diagnosis (PGD) and donated for cell line derivation by a family in which the mother was an expansion carrier (originally diagnosed as a carrier of an expansion with >40 repeats in blood by a repeat primed PCR). In addition, we generated halo-identical and unrelated C9/ALS iPSCs from a skin biopsies of the C9 carrier mother (patient H, 30 years-old), and from an unrelated C9/ALS patient, 2 years following disease-onset (patient M, 65 years-old).

ORGANISM(S): Homo sapiens

PROVIDER: GSE87273 | GEO | 2016/10/09

SECONDARY ACCESSION(S): PRJNA343952

REPOSITORIES: GEO

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