Genomics

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Comprehensive functional screening of miRNAs involved in human fat cell insulin sensitivity


ABSTRACT: The aim of this study was to detect and functionally investigate miRNAs linked to insulin sensitivity in human subcutaneous white adipose tissue (scWAT). Subjects were selected based on the insulin-stimulated lipogenesis response of subcutaneous adipocytes. Eleven miRNAs displayed differential expression between OIR and OIS states. Overexpression of miR-143-3p and miR-652-3p increased insulin-stimulated lipogenesis in human in vitro-differentiated adipocytes. MicroRNAs-143-3p and -652-3p are linked to scWAT insulin resistance independently of obesity.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE87379 | GEO | 2017/05/01

SECONDARY ACCESSION(S): PRJNA344564

REPOSITORIES: GEO

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