Interferon regulated genes in mouse intestine after irradiation and prophylactic Rig-I activation
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ABSTRACT: As RIG-I activation induces potent IFN-I responses,we analyzed the role of IFN-I in intestinal tissue protection and prevention of GVHD. We performed RNA sequencing with tissue samples from SI of WT mice that received TBI -/+ previous 3pRNA treatment and -/+ antibody-mediated blockade of IFNAR. Application of 3pRNA before TBI resulted in a significant increase of IFN-inducible genes in the SI as compared to solely irradiated mice. Blockade of IFNAR signaling abrogated 3pRNA-mediated up-regulation of IFN-induced genes, demonstrating that RIG-I-induced gene-regulation depends on IFN-I.
ORGANISM(S): Mus musculus
PROVIDER: GSE87386 | GEO | 2017/04/24
SECONDARY ACCESSION(S): PRJNA344762
REPOSITORIES: GEO
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