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The destiny of the resistance/susceptibility against GCRV has been congenitally destined by epigenetic mechanism in CIK cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Ctenopharyngodon idella

PROVIDER: GSE87414 | GEO | 2016/09/28

SECONDARY ACCESSION(S): PRJNA344679

REPOSITORIES: GEO

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The destiny of the resistance/susceptibility against GCRV has been congenitally destined by epigenetic mechanism in CIK cells [miRNA-seq]

Project description:In this study, the resistant and susceptible monoclonal CIK cell lines were first established which would be the ponderable research models for the nosogenesis mechanism of the hemorrhagic disease. C1 (CIK cells), R2 (resistant cells) and S3 (susceptible cells) samples were carried out RNA-Seq, MeDIP-Seq and small RNA-Seq by the next-generation sequencing strategy, bioinformatics analysis as well as experimental verification. It was discovered that the aboriginality of CIK cells were gravitated to the susceptible trait. And the discrepancies between resistance and susceptibility against GCRV could primarily attribute to antioxidant activity, cell killing activity and cell proliferation regulation. Here we comprehensively present the profiling and characteristics of DNA methylation and microRNA in the resistant and susceptible CIK cells and proposed that high mCHH methylation distribution might be a characteristic modulator in C. idella. What’s more, a series of genes modulated by DNA methylation or microRNA were designated as potential biomarkers for the resistance breeding. This study laid the foundation and opened novel avenues for nosogenesis research on hemorragic disease of C. idella.

2016-09-28 | GSE87413 | GEO

The destiny of the resistance/susceptibility against GCRV has been congenitally destined by epigenetic mechanism in CIK cells [RNA-seq]

2016-09-28 | GSE87408 | GEO

The destiny of the resistance/susceptibility against GCRV has been congenitally destined by epigenetic mechanism in CIK cells (MeDIP-seq)

2016-09-28 | GSE87405 | GEO

The destiny of the resistance/susceptibility against GCRV is controlled by epigenetic mechanisms in CIK cells.

Project description:Hemorrhagic disease caused by grass carp reovirus (GCRV) has severely threatened the grass carp (Ctenopharyngodon idella) cultivation industry. It is noteworthy that the resistance against GCRV infection was reported to be inheritable, and identified at both individual and cellular levels. Therefore, this work was inspired and dedicated to unravel the molecular mechanisms of fate decision post GCRV infection in related immune cells. Foremost, the resistant and susceptible CIK (C. idella kidney) monoclonal cells were established by single cell sorting, subculturing and infection screening successively. RNA-Seq, MeDIP-Seq and small RNA-Seq were carried out with C1 (CIK cells), R2 (resistant cells) and S3 (susceptible cells) groups. It was demonstrated that genome-wide DNA methylation, mRNA and microRNA expression levels in S3 were the highest among three groups. Transcriptome analysis elucidated that pathways associated with antioxidant activity, cell proliferation regulation, apoptosis activity and energy consuming might contribute to the decision of cell fates post infection. And a series of immune-related genes were identified differentially expressed across resistant and susceptible groups, which were negatively modulated by DNA methylation or microRNAs. To conclude, this study systematically uncovered the regulatory mechanism on the resistance from epigenetic perspective and provided potential biomarkers for future studies on resistance breeding.

| S-EPMC5495752 | biostudies-literature

The destiny of the resistance/susceptibility against GCRV has been congenitally destined by epigenetic mechanism in CIK cells

Project description:The destiny of the resistance/susceptibility against GCRV has been congenitally destined by epigenetic mechanism in CIK cells

| PRJNA344679 | ENA

An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior

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The epigenetic signature of systemic insulin resistance in obese women

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Cell of origin epigenetic priming determines susceptibility to Tet2 oncogenic mutation

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-14 | GSE247970 | GEO

Genotype-by-diet interactions determine susceptibility and resistance in T2D mouse models

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-31 | GSE235498 | GEO

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