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Layer-specific ATAC-seq of the neurons of adult mouse visual cortex defined by Cre-driver lines


ABSTRACT: Mammalian cortex is a laminar structure, with each layer composed of a characteristic set of cell types with different morphological, electrophysiological, and connectional properties. Here, we define chromatin accessibility landscapes of major, layer-specific excitatory classes of neurons, and compare them to each other and to inhibitory cortical neurons using the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq). We surveyed five Cre-reporter-labeled mouse cell lines using ATAC-Seq of 500-cell populations.

ORGANISM(S): Mus musculus

PROVIDER: GSE87548 | GEO | 2017/01/01

SECONDARY ACCESSION(S): PRJNA345167

REPOSITORIES: GEO

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