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Gene expression in the mouse brain following early pregnancy exposure to ethanol

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE87736 | GEO | 2016/10/07

SECONDARY ACCESSION(S): PRJNA347291

REPOSITORIES: GEO

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Gene expression in the mouse brain following early pregnancy exposure to ethanol.

Project description:Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system [1]. Behavioural and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity [2]. The economic and social costs of these outcomes are substantial and profound [3], [4]. Improvement of neurobehavioural outcomes following prenatal alcohol exposure requires greater understanding of the mechanisms of alcohol-induced damage to the brain. Here we use a mouse model of relatively moderate ethanol exposure early in pregnancy and profile gene expression in the hippocampus and caudate putamen of adult male offspring. The effects of offspring sex and age on ethanol-sensitive hippocampal gene expression were also examined. All array data are available at the Gene Expression Omnibus (GEO) repository under accession number GSE87736.

| S-EPMC5079349 | biostudies-literature

Gene expression in the mouse brain following early pregnancy exposure to ethanol [CaudatePutamen_Males_P87]

Project description:Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system. Behavioral and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity. The economic and social costs of these outcomes are substantial and profound. Improvement of neurobehavioural outcomes following prenatal alcohol exposure requires greater understanding of the mechanisms of alcohol-induced damage to the brain. Here we use a mouse model of relatively moderate ethanol exposure early in pregnancy and profile gene expression in the hippocampus and caudate putamen of adult male offspring. The effects of offspring sex and age on ethanol-sensitive hippocampal gene expression were also examined.

2016-10-20 | GSE87699 | GEO

Gene expression in the mouse brain following early pregnancy exposure to ethanol [Hippocampus_Males_P21]

Project description:Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system. Behavioral and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity. The economic and social costs of these outcomes are substantial and profound. Improvement of neurobehavioural outcomes following prenatal alcohol exposure requires greater understanding of the mechanisms of alcohol-induced damage to the brain. Here we use a mouse model of relatively moderate ethanol exposure early in pregnancy and profile gene expression in the hippocampus and caudate putamen of adult male offspring. The effects of offspring sex and age on ethanol-sensitive hippocampal gene expression were also examined.

2016-10-20 | GSE87703 | GEO

Gene expression in the mouse brain following early pregnancy exposure to ethanol [Hippocampus_Females_P87]

Project description:Exposure to alcohol during early embryonic or fetal development has been linked with a variety of adverse outcomes, the most common of which are structural and functional abnormalities of the central nervous system. Behavioral and cognitive deficits reported in individuals exposed to alcohol in utero include intellectual impairment, learning and memory difficulties, diminished executive functioning, attention problems, poor motor function and hyperactivity. The economic and social costs of these outcomes are substantial and profound. Improvement of neurobehavioural outcomes following prenatal alcohol exposure requires greater understanding of the mechanisms of alcohol-induced damage to the brain. Here we use a mouse model of relatively moderate ethanol exposure early in pregnancy and profile gene expression in the hippocampus and caudate putamen of adult male offspring. The effects of offspring sex and age on ethanol-sensitive hippocampal gene expression were also examined.

2016-10-20 | GSE87700 | GEO

Gene expression in the mouse brain following early pregnancy exposure to ethanol

Project description:Gene expression in the mouse brain following early pregnancy exposure to ethanol

| PRJNA347291 | ENA

Change in lncRNA and mRNA content of brain-derived extracellular vesicles following chronic intermittent ethanol vapor exposure in mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-01-23 | GSE194161 | GEO

Gene expression in the mouse embryo following early pregnancy exposure to ethanol or nicotine

Project description:The in utero environment is a critical determinant of the immediate and future health of the developing fetus. Two of the most commonly used drugs during pregnancy are alcohol and nicotine. While prolonged gestational exposure to alcohol or nicotine has been associated with a range of adverse outcomes in the offspring, the consequences of exposure during early gestation only are less well understood. Here, we use mouse models of relatively moderate early gestational ethanol or nicotine exposure to profile gene expression in whole male embryos at 9.5 days post coitum using an Illumina microarray.

2021-08-18 | GSE94347 | GEO

Expression data from adult mouse brain regions following prenatal infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-01 | E-GEOD-77973 | biostudies-arrayexpress

The Deciphering of Mouse Uterine Microenvironment during Early Pregnancy

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-07-30 | GSE181170 | GEO

Expression data from adult mouse brain regions following prenatal infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-03-01 | GSE77973 | GEO