Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cooptation of tandem DNA repeats for the control of epithelial-to-mesenchymal transition.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE88738 | GEO | 2018/05/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

TET1 regulates hypoxia-induced epithelial-mesenchymal transition through DNA demethylation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-01 | E-GEOD-59990 | biostudies-arrayexpress

Cooptation of tandem DNA repeats for the control of epithelial-to-mesenchymal transition [ChIP-Seq]

Project description:During normal or pathological epithelial-to-mesenchymal transition, epithelium-specific gene expression is shut down, with the DNA-binding factor ZEB1 acting as a master suppressor of epithelial identity. Here, we show that ZEB1 occupies primate-specific tandem repeats (TRs) harboring dozens of copies of its DNA-binding motif and located within genomic loci relevant for epithelial identity. Deletion of one such repeat in a quasi-mesenchymal human cancer cell line induced the reacquisition of epithelial features and phenocopied the effects of ZEB1 gene deletion. Since ZEB1 binds clustered motifs in a non-cooperative manner, changes in its nuclear concentration enable graded adjustments of TR occupancy, thus fine-tuning repression level. In addition, high motif density in TRs allows ZEB1 binding (and shutdown of epithelial programs) despite differences in chromatin organization and accessibility among epithelial cell types.

2018-05-02 | GSE88734 | GEO

Cooptation of tandem DNA repeats for the control of epithelial-to-mesenchymal transition [miRNA-Seq]

2018-05-02 | GSE88733 | GEO

Cooptation of tandem DNA repeats for the control of epithelial-to-mesenchymal transition [RNA-Seq]

2018-05-02 | GSE88735 | GEO

DNA methylation and gene expression analysis of an Epithelial-to-mesenchymal transition model

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-14 | E-GEOD-48527 | biostudies-arrayexpress

Architecture of Epigenetic Reprogramming Following Twist1 Mediated Epithelial-Mesenchymal Transition

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-10 | E-GEOD-53026 | biostudies-arrayexpress

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition