Genomics

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ChIP-Seq analysis C57BL/6 thymocytes


ABSTRACT: In this study, we show that in addition to regulating DP thymocytes survival, RORgT also controls genes that regulate thymocyte migration, proliferation, and T cell receptor (TCR) selection. Strikingly, pharmacological inhibition of RORg skews TCR gene rearrangement, limits T cell repertoire diversity, and inhibits development of autoimmune encephalomyelitis. Thus, targeting RORgT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens.

ORGANISM(S): Mus musculus

PROVIDER: GSE88916 | GEO | 2016/10/20

SECONDARY ACCESSION(S): PRJNA349114

REPOSITORIES: GEO

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