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MicroRNA expression profiling in tumor prostate samples from recurrent and non-recurrent cases

ABSTRACT: We investigated the relative miRNA levels in primary prostate cancer samples from patients that had a subsequent recurrence event versus patients that did not. For one of the top miRNAs arising from this analysis, miR-33a, we carried out further investigation, including miRNA levels in normal and tumor prostate samples as well as PCa cell lines. Then, we performed a detailed functional analysis of mir-33a in LNCaP and VCaP PCa cells and evaluated proliferative, invasive and anchorage independent growth potential of cells upon overexpression and knockdown of miR-33a.

ORGANISM(S): Homo sapiens

PROVIDER: GSE88958 | GEO | 2018/02/27

REPOSITORIES: GEO

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