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Genome-wide analysis of SAK-HV treatment caused hepatic genes expression in ApoE knockout mice

ABSTRACT: A novel recombinant fusion protein (SAK-HV) significantly decreased the serum levels of both total cholesterol (TC) and triglyceride (TG) in apolipoprotein E-deficient (ApoE-/-) mice with hyperlipemia and remarkably ameliorated hepatic steatosis. Particularly, its lipid-lowering effect was significantly better than that of atorvastatin during the observation period of 2 weeks. We then collected the liver tissues of SAK-HV-treated ApoE-/- mice (n=7) and liver tissues of PBS-treated ApoE-/- mice to make the transcriptome chip, and analyze the lipid-lowering mechanism of SAK-HV in liver of ApoE-/- mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE88964 | GEO | 2017/06/13

SECONDARY ACCESSION(S): PRJNA349254

REPOSITORIES: GEO

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