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Gene expression profiling of three human prostate epithelial subpopulations

ABSTRACT: The human prostate epithelium is predominantly comprised of two cell-types: basal and luminal. While basal cells exhibit significant progenitor activity in a variety of functional assays, luminal cells are depleted of this activity. Recent studies indicate that approximately 1% of luminal cells exhibit progenitor activity. We have discovered that differential expression of the glycoprotein CD38 can fractionate the luminal population into two subsets: CD38+ and CD38-low. In functional assays, the CD38-low luminal cells exhibit roughly 5-fold increased progenitor activity compared to the remaining CD38+ population. Therefore, we propose that CD38-low luminal cells represent an enriched luminal progenitor population while the CD38+ subset is predominantly comprised of mature non-progenitor luminal cells. In this microarray experiment, we have performed expression profiling of three epithelial subsets (basal, CD38-low luminal progenitor, and CD38+ mature luminal) purified by Fluorescence Activated Cell Sorting from the benign prostate of four different patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE89050 | GEO | 2016/10/22

SECONDARY ACCESSION(S): PRJNA350004

REPOSITORIES: GEO

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