Impact of IL-27 on hepatocyte antiviral gene expression and function
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ABSTRACT: IL-27 has been shown to play a role in modulating functions of diverse cell types like Th1, Th2, NK and B cells demonstrating both pro and anti-inflammatory roles. It is also capable of inducing STAT1, STAT3 and ISG's. To investigate the role of IL-27 on hepatocytes, Huh7.5 cells were treated with Il-27 and analysed the differentially expressed genes by microarray analysis. Microarray analysis showed that the upregulated genes belonged to antigen presentation and DNA replication pathways and involved strong upregulation of CXCL-10 a gene associated with liver inflammation.
ORGANISM(S): Homo sapiens
PROVIDER: GSE89610 | GEO | 2016/11/09
SECONDARY ACCESSION(S): PRJNA352859
REPOSITORIES: GEO
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