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Transcriptional response to early life stress in male and female mouse brain

ABSTRACT: This study explored the interaction of early life and adult stress on transcriptional and chromosomal states in a 2x2 design. Male and female mice were subjected to early life stress (ELS) or were standard-reared (Std), were housed normally through adolescence, and were then exposed to 10 days of control (Ctl) or chronic social defeat stress (CSDS: males only) or 3 days of sub-threshold variable stress (STVS: females only) conditions in adulthood. Long-lasting transcriptional alterations were assessed in the ventral tegmental area (VTA), nucleus accumbens (NAc), medial prefrontal cortex (PFC), and ventral hippocampus (HIP, males only) in adulthood.

ORGANISM(S): Mus musculus

PROVIDER: GSE89692 | GEO | 2017/06/28

SECONDARY ACCESSION(S): PRJNA352967

REPOSITORIES: GEO

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