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Genotype specific phenotypic behaviour of auxotrophic and prototrophic gene deletion collections

ABSTRACT: To systematically characterize the phenotypic behavior of two 'prototrophic' version of the Yeast Knockout (YKO) gene deletion collection, we compared genome-wide finess assays across a diverse set of drug and environmental conditions. This analysis uncovered experimental liabilities in the the prototrophic collections distinct from the YKO auxotrophies that shows that auxotrophic repair (regardless of methodology) does not restore wildtype behaviour.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE89761 | GEO | 2017/08/11

REPOSITORIES: GEO

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